Synthesis, Characterization and Biological Activity of Various Substitutedquinazolinone Derivatives Containing Dopamine Moiety
نویسندگان
چکیده
A Series of 3-Substituted phenyl 2-(3,4-dihydroxyphenyl ethyl amino)-6-substituted quinazolin-4-(3H) ones (4a-4h) have been synthesized by the reaction of 3-Substituted phenyl -2-methylbromo-6-substituted quinazolin-4-(3H) ones (3a-3h) with dopamine (3,4 dihydroxy phenyl ethyl amine). The biological screening showed that compound 4f namely 3-(2-Chloro phenyl)2-(3, 4-dihydroxyphenyl ethyl amino)-6-bromo quinazolin-4-(3H)one has shown most potent antiparkinsonian activity. The structure assignment of the new compounds based on chemical and spectroscopic evidence. The detailed synthesis spectroscopic data and pharmacological properties are reported.
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